File of the category ‘multiple sclerosis‘
Resource: Medline Bonus
As Medline Plus defines it, the multiple escleroris is an autoimmune illness that affects the brain and the spinal cord (central nervous system). The multiple sclerosis (EM) affects more the women than to the men. The most usual thing is that this disorder appears between 20 and 40 years of age, but it is possible to observe at any age.La esclerosis múltiple (EM) afecta más a las mujeres que a los hombres. Lo más usual es que este trastorno aparezca entre los 20 y 40 años de edad, pero se puede observar a cualquier edad.
The multiple sclerosis is caused by the damage to the sheath of mielina, the
protective covering that surrounds the neurons. When this covering of the nerves is damaged, the nervous impulses diminish or stop.
This illness is progressive, what means that the damage to the nerves (neurodegeneración) deteriorates in the course of time. The rapidity with which it deteriorates changes from one person to other one. To the nerve it is hurt inflammation, which happens when the immune cells of the proper body attack the nervous system. Repetitive inflammation episodes can appear along any area of the brain or of the spinal cord. El daño al nervio es causado inflamación, la cual ocurre cuando las células inmunitarias del propio cuerpo atacan el sistema nervioso. Se pueden presentar episodios repetitivos de inflamación a lo largo de cualquier área del cerebro o de la médula espinal.
The investigators are not sure on what it unleashes the inflammation. The most frequent theories point towards a virus or a genetic defect, or a combination of both.
The symptoms change because the location and magnitude of every attack can be different. The episodes can last days, weeks or months and they alternate with periods of reduction or absence of the symptoms (references).
The fever, the warm baths, the exhibition to the sun and the stress can unleash or worsen the attacks.
Because the nerves in any part of the brain or the spinal cord can turn out to be damaged, the patients with multiple sclerosis can have symptoms in many parts of the body.
Muscular symptoms:
- Loss of the balance
- Numbness or abnormal sensation in any area
- Decrease of the aptitude to control small movements
- Pain due to muscular spasms
- Pain in arms and legs
- Problems to move the arms and the legs
- Problems with the coordination and to do small movements
- Difficulty of speaking or of understanding the language
- Quake in one or both arms or legs
- Uncontrollable spasm of groups of muscles (muscular spasticity)
- Weakness in one or both arms or legs
Ocular symptoms:
- Double vision
- Inconvenience in the eyes
- Rapid and uncontrollable ocular movements
- Loss of vision (usually fond an eye simultaneously)
Other cerebral and neurological symptoms:
- Decrease of the period of attention
- Decrease of the aptitude to discern
- Decrease of the memory
- Depression or feelings of sadness
- Sickness or loss of the balance
- Facial pain
- Hipoacusia
- Fatigue
Symptoms vesicales and intestinal:
- Constipation
- Difficulty of beginning to urinate
- Frequent need to urinate
- Dregs leakage
- Intense urgency of urinating
- Leakage of urine (incontinence)
Priest is not known for the multiple sclerosis until now; nevertheless, there exist therapies that can slow down the progress of the illness. The target of the treatment is to control the symptoms and to maintain a normal quality of life.
Complications
- Depression
- Difficulty of swallowing
- Difficulty of thinking
- Less and less aptitude to take care of himself
- Need for a permanent probe
- Osteoporosis or slimming of the bones
- decubitus ulcers
- Side effects of the medicines used to treat the disorder
- Urinal infections
Situations that need medical care
Consult with the doctor if:
- It develops any multiple sclerosis symptom.
- The symptoms deteriorate, even with treatment.
- The complaint deteriorates up to the point in which the care is already not possible in the hearth.
References
Calabresi P. Multiple central sclerosis and demyelinating conditions of the nervous system. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 436. Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier;2007:chap 436.
Gray OM, McDonnell GV, Forbes RB. To systematic review of oral multiple methotrexate for sclerosis. Mult Scler. 2006; 12:507-510.Mult Scler. 2006;12:507-510.
Farinotti M, Simi S, Di Pietrantonj C, McDowell N, Brait L, Lupo D, Filippini G. Multiple Dietary interventions for sclerosis. Cochrane Database Syst Rev. 2007 Seed drill 24; (1):CD004192.Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004192.
Miller DH, Leary SM. Multiple Primary-progressive sclerosis. Lancet Neurol. 2007; 6:903-912.Lancet Neurol. 2007;6:903-912.
Updated: 1/21/2009 Date of review: Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc. Daniel B. Hoch, PhD, MD, Assistant Professor of Neurology, Harvard Medical School, Department of Neurology, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.





