Factors of Transference

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The majority of the alternative and complementary treatments against the cancer presented as this magazine in the last months has a common factor: they confront the illness by means of the use of substances or procedures directed to promote the immune system and to improve this way its yield opposite to the tumor cells with a physical and mental cost infinitely less than the chemotherapy and the radiotherapy suppose. Because all of them might be considered to be tricks of the immune system in the struggle against the cancer. Porque todos ellos podrían considerarse bazas del sistema inmune en la lucha contra el cáncer.

That the immune system allows not only to confront any pathology but in many cases to prepare them we know it since it was discovered that we can immunize ourselves by means of the use of vaccines. It was in 1776 when a medical Englishman called Edward Jenner administered the first one: against the smallpox. Jenner had observed that the baby's mistresses that were contagious of the smallpox of the cows - that does not cause important problems of health - seemed to remain protégées before the human smallpox - normally mortal-. And to verify if it was like that on May 14, 1796 it inoculated in the body of a child called James Phipps pus proceeding from the pustule of a woman infected with the smallpox of the cow. On June 1, once the boy recovered of the infection, Jenner would inoculate the human smallpox. And as he was waiting, the boy never developed the illness. Jenner would name to its technical "vaccination", term that derives precisely from the Latin word “vacca“. contra la viruela. Jenner había observado que las amas de cría que se contagiaban de la viruela de las vacas -que no causa problemas de salud importantes- parecían quedar protegidas ante la viruela humana -normalmente mortal-. Y para comprobar si era así el 14 de mayo de 1796 inoculó en el cuerpo de un niño llamado James Phipps pus procedente de la pústula de una mujer infectada con la viruela de la vaca. El 1 de junio, una vez el muchacho se recuperó de la infección, Jenner le inocularía la viruela humana. Y como esperaba, el muchacho nunca desarrolló la enfermedad. Jenner denominaría a su técnica “vacunación”, término que deriva precisamente de la palabra latina “vacca”.
Namely that without having not even idea of how it happened - the first reference to the existence of the viruses the botanist Dimitri Ivanovsky did almost one century later, in 1892 - Edward Jenner had given the first steps in the ambience of the Immunotherapy discovering an effective way of preventing the persons from developing serious illnesses.

Curiously the connection between the cancer and the immune system would be discovered two years earlier - in 1890 - when its complicated functioning mechanisms were still ignored. This year the medical New Yorker William B. Colaw had remained intrigued before the disappearance of malignant tumors in patients of cancer who had contracted infections estreptocócicas sharp and suspecting that the natural answer of the organism to the bacterial infection could be the person in charge of the retrogression of the tumor he decided to realize an experiment and injected living streptococci into a patient with an unoperable cancer to see if the tumor was sending. Well, after three bacterial cultivation … the quarter: it produced the finished disappearance of the tumor! Coley se había quedado intrigado ante la desaparición de tumores malignos en pacientes de cáncer que habían contraído infecciones estreptocócicas agudas y sospechando que la respuesta natural del organismo a la infección bacteriana podía ser la responsable de la regresión del tumor decidió realizar un experimento e inyectó estreptococos vivos en un paciente con un cáncer inoperable para ver si el tumor remitía. Pues bien, tras tres cultivos bacterianos… el cuarto ¡produjo la desaparición completa del tumor!
Colaw continued its investigation up to developing a miscellany of dead bacteria - that ended up by being an acquaintance like “the toxins of Colaw” - and treated, along with other doctors, more than 1.000 patients of cancer with them. Obtaining an unequal success. So since the results were unforeseeable the therapeutic method would end up by falling into oblivion. Así que como los resultados eran imprevisibles el método terapéutico terminaría cayendo en el olvido.

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Already in 1909 a scientific called Paul Ehrlich affirmed for the first time that the incidence of the cancer would be much major if it was not for the alertness of the immune system, capable of eliminating and of identifying the newly divided tumor cells. With what then it set already to our defense system in the center of the control of the tumor growth. Approximately 50 years later two scientists-Lewis Thomas and Frank MacFarlane Burnet - would recapture the conviction of Paul Ehrlich and they communicated that a special type of immune cell - the “cell T” - was the central pivot of the answer of the immune system against the cancer. It led to the minting of the expression “immune alertness” to describe the permanent attitude of alert of the immune system against the cancerous cells. Nevertheless, this affirmation generated a notable polemic that it would continue up to the publication on April 26, 2001 of an investigation in the magazine titled Nature “IFN-Gamma and the lymphocytes prepare the development of the primary tumor and form the inmunogenicidad of the tumor”. The article was written by Robert D. Schreiber and its companions of the Washington University School of Medicine de St. Louis in collaboration with Lloyd J. Old - doctor of Ludwig Institute for Cancer Research and of the Brief Sloan-Kettering Cancer Center of New York-. The experimental evidence presented in the document demonstrated unequivocally that the immune system prevents to the tumors from developing - and often even that appear - playing so an important protective role opposite to the cancer. Aproximadamente 50 años después dos científicos -Lewis Thomas y Frank MacFarlane Burnet- retomarían la convicción de Paul Ehrlich y comunicaron que un tipo especial de célula inmunitaria -la “célula T”- era el pivote central de la respuesta del sistema inmune contra el cáncer. Ello llevó a la acuñación de la expresión “vigilancia inmune” para describir la actitud permanente de alerta del sistema inmunitario contra las células cancerosas. Sin embargo, esa afirmación generó una notable polémica que continuaría hasta la publicación el 26 de abril del 2001 de una investigación en la revista Nature titulada “IFN-gamma y los linfocitos previenen el desarrollo del tumor primario y configuran la inmunogenicidad del tumor”. El artículo estaba escrito por Robert D. Schreiber y sus colegas de la Washington University School of Medicine de St. Louis en colaboración con Lloyd J. Old -médico del Ludwig Institute for Cancer Research y del Memorial Sloan-Kettering Cancer Center de Nueva York-. La evidencia experimental presentada en el documento demostró inequívocamente que el sistema inmune impide a los tumores desarrollarse -y a menudo incluso que aparezcan- jugando pues un importante papel protector frente al cáncer.

Since it was of foreseeing today they are increasingly the scientists who study the relation between the immune system and the tumor cells. Being between the strategies most used at present inside the wide experimental field of the Immunotherapy the patients' immunization with material designed to provoke an answer capable of eliminating or of the tumor growth slowing down. In this group it would be necessary to include the works with tumor antigens since the identification of genes that codify the chains formation peptídicas in the cellular surface of the tumors and that can be recognized by the cells T they provide the theoretical base for its functioning. In contrast to most of the vaccines used with the infectious agents the antitumoral Immunotherapy would activate the immune answer against certain antigens to which it has been already exhibited previously. For that reason the vaccination with antigens that express proteins and péptidos tumor it might improve the efficacy of our immune system against the tumor processes. Let's remember, in this sense, the vaccines with antigens of the urine prepared by the Mexican doctor Salvador Capistrán (see the released thing on this matter in the isolated "Cancer" of our web). En este grupo cabría incluir los trabajos con antígenos tumorales ya que la identificación de genes que codifican la formación de cadenas peptídicas en la superficie celular de los tumores y que pueden ser reconocidas por las células T proporcionan la base teórica para su funcionamiento. A diferencia de la mayoría de las vacunas empleadas con los agentes infecciosos la Inmunoterapia antitumoral activaría la respuesta inmune contra ciertos antígenos a los cuales ya ha sido expuesto anteriormente. Por esa razón la vacunación con antígenos que expresen proteínas y péptidos tumorales podría mejorar la eficacia de nuestro sistema inmune contra los procesos tumorales. Recordemos, en este sentido, las vacunas con antígenos de la orina elaboradas por el doctor mexicano Salvador Capistrán (vea lo publicado al respecto en el apartado “Cáncer” de nuestra web).
Very well, since there correspond to this investigation line the works realized with the factors of transference about which we are going to speak and that can be generic or specific for every pathology.

THE "MEMORY" OF THE IMMUNE SYSTEM

In 1949 doctor H. Sherwood Lawrence used extracts of leukocytes or white globules to demonstrate that the immune answer is transferred of a human being who gives positive to the exhibition to a specific antigen to a recipient that gives negative … across small proteins to which it called transference factors. The superficial annoyance (the positive answer) in the subject that previously had not shown any answer of the immune system before the specific antigen was demonstrating that this one yes took place and that the immune system had acquired across the transference factor knowledge on the specific antigen. The important of Lawrence's investigation was that it demonstrated that the “immune memory” was transmitted without need to inoculate real antibodies. There were enough the factors of transference, proteins of low molecular weight. Lo importante de la investigación de Lawrence fue que demostró que la “memoria inmune” era transmitida sin necesidad de inocular anticuerpos reales. Bastaba con los factores de transferencia, proteínas de bajo peso molecular.

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Of course, there are still those who deny today the reality of the factors of transference. Although it is not, certainly, the case of those who work with them. As the doctor Sergio Estrada - investigator of the Department of Immunology of the National School of Biological Sciences of the National Polytechnic school of Mexico and member of the Mexican Society of Immunology - the one who works for already 30 years with the growth factors. “Nobody believed Lawrence at first - would say to us the doctor Estrada - and there are still many people who neither wants to believe, he does not even want to know anything about the Factor of Transference. But they become convinced when they begin treating the patients with the product”. Como el doctor Sergio Estrada -investigador del Departamento de Inmunología de la Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional de México y miembro de la Sociedad Mexicana de Inmunología- quien trabaja desde hace ya 30 años con los factores de crecimiento. “Nadie creyó a Lawrence al principio -nos diría el doctor Estrada- y todavía hay mucha gente que no quiere creer, ni quiere saber nada del Factor de Transferencia. Pero se convencen cuando empiezan a tratar a los pacientes con el producto”.

Come to this point it is necessary to tell that the transference factors are chains peptídicas composed of tens amino acids that seem to store all the experience of the immune system. The big intellectual jump is to understand that the transference factors neither transfer antibodies they do not even create them straight but its function is that of educating, teaching to the cells of the immune system to recognize specific antigens that they should go unnoticed. That's why it is as what probably the allopathic medicine has problems to admit its existence and its therapeutic possibilities. It is a question, in sum, of a vision completely different from the normal pharmacological models. Por eso es por lo que probablemente la medicina alopática tiene problemas para admitir su existencia y sus posibilidades terapéuticas. Se trata, en suma, de una visión completamente distinta de los modelos farmacológicos normales.

It is necessary to add that the transference factors do not treat anything but they work to do to the “more intelligent immune” system, so that it is the proper organism the one that could eliminate the illness. They are so vital in the development of the strategies of the immune system against the illness and the invading gérmenes. And they are also inmunomoduladores since they do not force a global but specific answer adapted to every occasion. Y son además inmunomoduladores ya que no fuerzan una respuesta global sino específica y adecuada a cada ocasión.

To understand its functioning it can be said that it is as if the transference factors were storing “chemical photos” of the viruses, bacteria, fungi and parasites with which they were in contact in the proper organism or in of others and they transmit this information to the cells entrusted to fight the illness in the organism where they are introduced.

And its possibilities are almost infinite judging by the declarations carried out by the doctor Estrada: "The transference factors are useful in the illnesses produced by bacteria, virus, yeasts and fungi. It is the case of illnesses as different as the tuberculosis (meningeal, renal and cutaneous), the leprosy, the coccidioidomicosis, the diabetes type II, the renal ailments, the earache, the herpes Zoster and simply, the hepatitis B, the toxoplasmosis, the leishmaniosi, the asthma, the dermatitis atópica, the rinitis, the rheumatoid arthritis, the psoriasis, the multiple sclerosis or the sjogren, between many others. And the same is necessary to say in the cases of cancer of kidney and prostate as well as in melanomas and linfomas.” Y lo mismo cabe decir en los casos de cáncer de riñón y próstata así como en melanomas y linfomas.”

THE FACTORS OF TRANSFERENCE IN BLOOD

And where to obtain the transference factors? The doctor Estrada has centred its work on the securing of the same ones from the blood. “They are obtained - he would tell to us - breaking the white globules or leukocytes of the blood and putting the obtained in a dialysis bag with a very thin mesh that only allows the exit of very small molecules - of 10 kilodaltones or minors - therefore they cannot spend virus, bacteria or fungi. Well, the obtained leukocytes extract contains a factor capable of transmitting the positive immune answer of the donor to the receiving organism. Such is the transference factor and it has an extraordinary, undeniable therapeutic activity”. “Se obtienen -nos explicaría- rompiendo los glóbulos blancos o leucocitos de la sangre y metiendo lo obtenido en una bolsa de diálisis con una malla muy fina que sólo permite la salida de moléculas muy pequeñas -de 10 kilodaltones o menores- por lo que no pueden pasar virus, bacterias u hongos. Pues bien, el extracto de leucocitos obtenido contiene un factor capaz de transmitir la respuesta inmune positiva del donante al organismo receptor. Tal es el factor de transferencia y tiene una actividad terapéutica extraordinaria, innegable”.
Sergio Estrada admits that when it began to work with the transference factors it did it of very skeptical form because it was not known what they were although it realized much its therapeutic activity. Hence using them out every time in more illnesses with the calmness of knowing that it is a question of an innocuous material.
As for the securing process Road was purifying it up to spending from generic factors of transference obtained from the blood of 1.000 healthy patients to transference factors more specifics that, of course, are necessary more complex processes.“ They exist already - he would say to us - quite definite molecules that transfer the specific immunity. There are molecules that have a molecular weight of five thousand daltones or five kilodaltones (Kda). And each of them is specific for a microorganism or for a different antigen. That assures the success of the therapy to us in infectious illnesses. It is necessary to give to the patients the specific factor for every suffering although there are sufferings that are practically universal like the herpes Zoster that comes from a complication of the chicken pox. But it is the same virus. Very well, so when of children we catch the chicken pox we spend it without complications and also it leaves to us a solid immunity that is reinforced whenever we have new meetings with the virus of the chicken pox. In such a way that the young people in Mexico, who are those who donate blood, has almost all immunity to the chicken pox. Also that's why a success is the treatment with transference factor in the herpes Zoster. There is nothing that he is compared. Today the habitual medical treatment for this ailment is the 'aciclovir' but I make sure him that the transference factor is much better. In a study that we did to blind double and that there published in ‘Journal of Inmunofarmacology’ the patients treated with the factor of transference were stopping having pain to ten days while the agreements with aciclovir were enduring still strong pains to the 22. What it demonstrates, of definitely statistical form, which is much better the transference factor in this suffering”. Son moléculas que tienen un peso molecular de cinco mil daltones o cinco kilodaltones (Kda). Y cada una de ellas es específica para un microorganismo o para un antígeno diferente. Eso nos asegura el éxito de la terapia en enfermedades infecciosas. Hay que dar a los pacientes el factor específico para cada padecimiento si bien hay padecimientos que son prácticamente universales como el herpes Zoster que proviene de una complicación de la varicela. Pero es el mismo virus. Bueno, pues cuando de niños pillamos la varicela la pasamos sin complicaciones y además nos deja una inmunidad sólida que se va reforzando cada vez que tenemos nuevos encuentros con el virus de la varicela. De tal manera que los jóvenes en México, que son los que donan sangre, tienen casi todos inmunidad a la varicela. También por eso es un éxito el tratamiento con factor de transferencia en el herpes Zoster. No hay nada que se le compare. Hoy el tratamiento médico habitual para esta dolencia es el ‘aciclovir’ pero le aseguro que el factor de transferencia es mucho mejor. En un estudio que hicimos a doble ciego y que se publicó en el ‘Journal of Inmunofarmacology’ los pacientes tratados con el factor de transferencia dejaban de tener dolor a los diez días mientras los tratados con aciclovir padecían aún fuertes dolores a los 22. Lo que demuestra, de forma estrictamente estadística, que es mucho mejor el factor de transferencia en este padecimiento”.

THE FACTORS OF TRANSFERENCE IN THE TREATMENT OF THE CANCER
The successes obtained by Sergio Estrada would lead a friend of his, the doctor Abelardo Monges Nicolau - specialist in Oncology of the Hospital Mocel - to proving the transference factors in cancer patients. Something that has doing for already ten years. “The truth is that I am impressed by the results - he confessed to us-. Basically I use them as a coadjutant method of the chemotherapy and must say that the expectation of life - in all kinds of cancers and metástasis - is very superior to the obtained one with the simple application of the conventional methods”. In spite of which the absence of funds - evil apparently structural in Mexico where we have seen promising investigations that never see the light for lack of economic support - it has prevented until now - this way it would confess to us Monges - the achievement of the expensive studies demanded for the securing of the official recognition. “La verdad es que estoy impresionado con los resultados -nos confesó-. Básicamente los utilizo como método coadyuvante de la quimioterapia y debo decir que la expectativa de vida -en todo tipo de cánceres y metástasis- es muy superior a la obtenida con la simple aplicación de los métodos convencionales”. A pesar de lo cual la falta de fondos -mal al parecer estructural en México donde hemos visto prometedoras investigaciones que no ven nunca la luz por falta de apoyo económico- ha imposibilitado hasta el momento -así nos lo confesaría Monges- la realización de los caros estudios exigidos para la obtención del reconocimiento oficial.
The doctor Estrada would make sure us for his part, that in countries as China the transference factors are used extensively to fight viral illnesses as the hepatitis B and C that they can cause hepatocarcinomas or cirrhosis. In this country the percentage of persons with the virus of the hepatitis who do not present symptomatology is very high what he suggests that its immune system is capable of stopping the action of the virus. That's why with the blood of these persons an extract is done dializable of white globules that are administered to the children as it "vaccinates" with the intention of which they do not develop the hepatitis even if they become infected with the virus. Also they are used in Cuba, Slovakia and Italy with a cost much underneath of which the treatment needs, for example, with interferon. Por eso con la sangre de esas personas se hace un extracto dializable de glóbulos blancos que se administra a los niños como “vacuna” con el propósito de que no desarrollen la hepatitis aún cuando se infecten con el virus. También se utilizan en Cuba, Eslovaquia e Italia con un costo muy por debajo del que requiere, por ejemplo, el tratamiento con interferón.
And this is its third advantage: it is easy to obtain, it has no side effects and its production cost is very low compared to other products like the interferones and the interleuquinas. What clearly would benefit the patients, especially in the Third World. “For the treatment of a linfoma - he affirms Road - the cells B have in its surface a chemical group that calls CD20 and there is an antibody monoclonal capably of adhering to him that allows to eliminate the cancerous cells. The problem is that every injection costs 1.800 euros and several are needed by what many patients could not finish the treatment. The new therapies it is possible therefore that they are better but every time they are more expensive and inaccessible. On the other hand, the transference factor is an inmunomodulador within reach of the whole world, much easier to prepare and extraordinarily cheaper”. Lo que claramente beneficiaría a los enfermos, especialmente en el Tercer Mundo. “Para el tratamiento de un linfoma -afirma Estrada- las células B tienen en su superficie un grupo químico que se llama CD20 y hay un anticuerpo monoclonal capaz de adherirse a él que permite eliminar las células cancerosas. El problema es que cada inyección cuesta 1.800 euros y se requieren varias por lo que muchos pacientes no puedan terminar el tratamiento. Las nuevas terapias puede por tanto que sean mejores pero cada vez son más caras e inaccesibles. En cambio, el factor de transferencia es un inmunomodulador al alcance de todo el mundo, mucho más fácil de preparar y extraordinariamente más barato”.

THE COLOSTRUM
Another line of investigation - headed by big laboratories specializing in nutritional complements - supports that the transference factors it is possible them to obtain also of the colostrum of the milk - so much it humanizes like animal - very rich in proteins, between them all the antibodies (antibodies that defend the organism against the infections). And the fact is that it seems clear that the immune memory comes to the newborn baby across the colostrum, the first milk that it obtains of the breast of the mother. Today we know that during the last trimester of the gestation the mammary gland accumulates a substance called precolostrum formed principally for exudado of plasma, cells, antibodies, lactoferrina, seroalbúmina, sodium, chlorine and a small quantity of lactose. Later, in the first four days later to the childbearing, there takes place the colostrum, a yellowish and thick fluid of high thickness and scarce volume. Between 2 and 20 ml for capture, sufficient to satisfy the needs of the newborn baby. And that that the colostrum has less suppressed energy, lactose, lípidos, glucose, urea, hidrosolubles vitamins, PTH and nucleótidos that the mature milk. Nevertheless, it contains more proteins, siálico acid, vitamins liposolubles E, A, K and carotenos. The content in minerals as sodium, zinc, iron, sulfur, selenium, manganese and potassium also is top in the colostrum. But, especially, the colostrum has a very high antibodies content, especially IgA, lactoferrina, lymphocytes and macrophages, oligosacáridos, citoquinas and other defensive agents that protect the newborn babies of the environmental gérmenes and favor the maturation of its system of defense. It contains also intestinal enzymes that they help in the digestion (the lactasa and others intestinal enzymes are immature in the newborn baby). Its abundant antibodies cover the endotelio of the digestive pipe avoiding the adhesion of the pathogenic ones, it facilitates the colonization of the intestinal tract for lactobacilos bífidus and contains antirust that protect him from the damage oxidativo. Of all this there is deduced the fundamental importance that has for a newborn baby to begin its life taking the colostrum of its mother. Hoy sabemos que durante el último trimestre de la gestación la glándula mamaria acumula una sustancia llamada precalostro formada principalmente por exudado de plasma, células, inmunoglobulinas, lactoferrina, seroalbúmina, sodio, cloro y una pequeña cantidad de lactosa. Más tarde, en los cuatro primeros días posteriores al parto, se produce el calostro, un fluido amarillento y espeso de alta densidad y escaso volumen. Entre 2 y 20 ml por toma, suficiente para satisfacer las necesidades del recién nacido. Y eso que el calostro tiene menos contenido energético, lactosa, lípidos, glucosa, urea, vitaminas hidrosolubles, PTH y nucleótidos que la leche madura. Sin embargo, contiene más proteínas, ácido siálico, vitaminas liposolubles E, A, K y carotenos. El contenido en minerales como sodio, zinc, hierro, azufre, selenio, manganeso y potasio también es superior en el calostro. Pero, sobre todo, el calostro tiene un contenido muy elevado de inmunoglobulinas, especialmente IgA, lactoferrina, linfocitos y macrófagos, oligosacáridos, citoquinas y otros agentes defensivos que protegen a los recién nacidos de los gérmenes ambientales y favorecen la maduración de su sistema de defensa. Contiene además enzimas intestinales que ayudan en la digestión (la lactasa y otras enzimas intestinales están inmaduras en el recién nacido). Sus abundantes inmunoglobulinas cubren el endotelio del tubo digestivo evitando la adherencia de los patógenos, facilita la colonización del tracto intestinal por lactobacilos bífidus y contiene antioxidantes que le protegen del daño oxidativo. De todo ello se deduce la importancia fundamental que tiene para un recién nacido empezar su vida tomando el calostro de su madre.
Studies realized in animals suggest also that the lactoferrina - one of the main proteins found in the colostrum - can help to prepare or reduce the cancers of colon, bladder, language, esophagus and lung as well as the formation of metástasis of lung. The underlying mechanisms are low study but they seem to be related to the aptitude of the lactoferrina to improve the functioning of the immune system. It is necessary to add that the acid linoleico combined and other fats found in the colostrum also have showed anticarcinogenic properties. Cabe agregar que el ácido linoleico conjugado y otras grasas encontradas en el calostro también han mostrado propiedades anticancerígenas.
It is no wonder so that turning to the beginning of the immunology beech who has turned the look to the cows - that up to the appearance of the called "mad cow disease" was an animal prepared to resist a big number of microorganisms - in order to try to make use of the advantages of its colostrum. In fact, its use is not new. In the India, during thousands of years, the doctors ayurvédicos documented the benefits for the health of the colostrum. And in the Scandinavian countries there has been done during hundreds of years a delightful puding of covered colostrum of honey to celebrate the calves birth. It was even used in the United States like antibiotic up to the discovery of the penicillin. En la India, durante miles de años, los médicos ayurvédicos documentaron los beneficios para la salud del calostro. Y en los países escandinavos se ha hecho durante centenares de años un delicioso puding de calostro cubierto de miel para celebrar el nacimiento de terneros. Incluso fue utilizado en Estados Unidos como antibiótico hasta el descubrimiento de la penicilina.
In sum, numerous investigations have confirmed in the last years the possibility of benefiting from the animal colostrum - principally of the cows - to reinforce the immune system. And hence there are many nutritional complements that today contain it.
Now then, there was someone that even more background came and one raised that not even the large number of substances of the colostrum was sufficient to justify the qualitative jump that happens in the immune system of the baby. That it was lacking to know how without penetrating antibodies the mother transmits the immune memory to its son. And again the factors of Lawrence's transference were the answer. With what investigators and laboratories hurried to extract colostrum of the cows, they did an intense molecular filtration and ended up by finding a very small molecule: the transference factor. And they decided to commercialize them like nutritional complements of oral consumption. Y de nuevo los factores de transferencia de Lawrence fueron la respuesta. Con lo que investigadores y laboratorios se apresuraron a extraer calostro de las vacas, hicieron una intensa filtración molecular y terminaron encontrando una molécula muy pequeña: el factor de transferencia. Y se decidieron a comercializarlos como complementos nutricionales de consumo oral.

AMERICAN AND RUSSIAN TESTS
We must add that one of the most interesting investigations on the capacity of these products was the directed one by the doctor Darryl See who was the director of the Institute of Longevity Medicine of California and that it was employed at different occasions for Upjohn, Pfizer, Harvard and the Department of North American Defender. At present it directs a clinic in which it applies the transference factors to the cancer patients. The study had finally to determine the anticarcinogenic effects “in vitro” of two products of the company 4Life. And its conclusion could not be clearer.“ Both products - he affirmed - induce the destruction of the cells eritroleucémicas K562 at a level not known in the experience of the director of the investigation and in the well-known medical literature. Since the function of the so called natural killer cells is crucial to finish with the carcinogenic cells these products they are ideal candidates to be part of an adjuvant therapy in cases of cancer. Also the natural killer cells form the first defense line against the infections of virus and other microorganisms”. El estudio tenía por fin determinar los efectos anticancerígenos “in vitro” de dos productos de la empresa 4Life. Y su conclusión no pudo ser mas clara. “Ambos productos -afirmó- inducen la destrucción de las células eritroleucémicas K562 a un nivel desconocido en la experiencia del director de la investigación y en la literatura médica conocida. Dado que la función de las denominadas células asesinas naturales es crucial para terminar con las células cancerígenas estos productos son candidatos ideales para formar parte de una terapia adyuvante en casos de cáncer. Además las células asesinas naturales forman una primera línea de defensa contra las infecciones de virus y otros microorganismos”.
Darryl See would publish in February, 1999 an investigation in the Journal of the American Nutraceutical Association in which he was studying the aptitude of 196 natural and not poisonous products to increase the activity of the natural killer cells. Well, some products increased its activity in 48 ’6 % but the obtained factor of transference of the colostrum did it in 103 %. Also, when the transference factor was combined by a series of agents tímicos - the beta - glucanos of multiple sources, Acemanano and IP6 - the result was an increase sinergístico of the activity of the natural killer cells of 248 %. This combination of factor of calostral transference, tímicos factors and extracts of polysaccharides biologically active is the most active product proved up to the date. Además, cuando el factor de transferencia fue combinado con una serie de agentes tímicos -los beta-glucanos de fuentes múltiples, Acemanano e IP6- el resultado fue un incremento sinergístico de la actividad de las células asesinas naturales del 248%. Esta combinación de factor de transferencia calostral, factores tímicos y extractos de polisacáridos biológicamente activos es el producto más activo probado hasta la fecha.
In a third stage Darryl See realized a study “in I live” for what it selected twenty patients-12 men and 8 women - who were enduring cancers in phases III and IV. Its life expectancy was 49,3 years and all of them had been sent by its oncologists to die to house. The hope comes up of life that they had age of 3 ’7 months. Well, the protocol consisted of giving to every patient 9 daily capsules of factors of transference. And eight months later: 16 of them were still living! Some had improved, others were stabilized and in some the cancer: he was sending! It was stated also that the number of natural killer cells had increased - of average: in 400 %! La esperanza media de vida que tenían era de 3’7 meses. Pues bien, el protocolo consistió en dar a cada paciente 9 cápsulas diarias de factores de transferencia. Y ocho meses después ¡16 de ellos aún vivían! Unos habían mejorado, otros estaban estabilizados y en algunos el cáncer ¡estaba remitiendo! Se constató también que el número de células asesinas naturales había aumentado -de media- ¡en un 400%!
In the same line of the doctors Calvin McCausland and Emma Oganova tried to confirm the capacity of the factors of transference commercialized for 4Life they designed a study to prove its influence in the activity of the natural killer cells. Also the doctor Anatoli Vorobiev - of the Russian Academy of Medical sciences - directed a team in independent tests. Well, using citotoxicidad tests to blind double carcinogenic cells got together with natural killer human beings cells and there split between groups of killer cells not activated natives activated with factors of transference and groups of natural killer cells. The results demonstrated decisively the aptitude of the factors of transference to reinforce the activity of the natural killer cells in 283 % and, even, in case of the product most advanced in an extraordinary one 437 %, over any normal immune answer (answer established like base line of this study). Also the results of this scientific experiment demonstrated that the natural killer cells activated with factors of transference were killing 99 % of the carcinogenic cells what was overcoming the capacity of natural defense of the body. Pues bien, utilizando pruebas de citotoxicidad a doble ciego se combinaron células cancerígenas con células asesinas naturales de humanos y se dividieron entre grupos de células asesinas naturales activadas con factores de transferencia y grupos de células asesinas naturales no activadas. Los resultados demostraron concluyentemente la capacidad de los factores de transferencia para reforzar la actividad de las células asesinas naturales en un 283% e, incluso, en el caso del producto más avanzado en un extraordinario 437%, por encima de toda respuesta inmunitaria normal (respuesta establecida como línea de base de este estudio). Además los resultados de este experimento científico demostraron que las células asesinas naturales activadas con factores de transferencia mataban el 99% de las células cancerígenas lo que superaba la capacidad de defensa natural del cuerpo.
The Russian scientists, before so exceptional results, requested immediately major information about the contributed samples. “The sample of 4Life (compound Transfer Factor E-XF) promoted the activity of the natural killer cells more than the medicine Interleucina-2 (IL2) used in a standard way. Here we name now to its sample ‘the golden interleucina’”, the doctor Kisielevsky would transmit - member of the Russian Academy of Medical sciences - to the laboratory. Aquí denominamos ahora a su muestra ‘la interleucina de oro’”, transmitiría el doctor Kisielevsky -miembro de la Academia Rusa de Ciencias Médicas- al laboratorio.
In fact, the results have been so extraordinary that in last December - as the company affirms 4Life - the Russian Department of Health approved the use of its factors of transference as immune modulators in hospitals and clinics of the federation. The results of ten clinical essays and two experimental studies carried out on these products remained captured of the methodological document approved by the department that allows to the doctors to use them in its clinical practice.
Obviously it remains great for advancing in the field of the Immunotherapy and the transference factors - generic or specific - but be obtained of the blood or of the colostrum they are demonstrating to be a few promising therapeutic hardware - more that confirmed after 30 years of experience - in multitude of pathologies, between them the cancer. Although till now they have come using basically how compensating of the damage caused by the chemotherapy.

Antonio F. Wall

Source: Dsalud.com