Factors of Transference

Immunotherapy: Experience of Group Via Delphi in the use of the factors of transference.

The immunotherapy has offered the opportunity to transfer immune characteristics from one species to other one. Group Via Delphi has applied skills of immunotherapy rested on the factors of transference. The M.V.Z. Raúl Torres, manager of veterinary medicine of Group Via Delphi and its team, share for the Asdic readership its experience with the use of the factors of transference in our dolphins or dolphins.Raúl Torres, gerente de medicina veterinaria de Grupo Via Delphi y su equipo, comparten para los lectores de Sonar su experiencia con el uso de los factores de transferencia en nuestros delfines o toninas.

History of the immunotherapy

The main propulsion of the immunotherapy began when Edgard Jenner discovered the first vaccine against the smallpox, the above mentioned vaccine consisted of teaching to the immune system to fight against a dangerous infection. In the following decades I keep on being investigated in this direction until in 1909 Paul Ehrlich affirmed that the incidence of the cancer and of diverse illnesses would be much major if it was not for the aptitude of the immune system to identify the tumor and infected cells and to destroy them when the tumor even is small or the illness initiates its course infectivo.

History of the factors of transference

At the end of the 40s, while he was studying the tuberculosis, Dr. H. Sherwood Lawrence determined that a substance in an extract of leukocytes (white globules) seizure of an individual who had recovered of the tuberculosis could transfer him to a recipient that there had not been infected yet a positive immune answer to the tuberculosis, that is to say it would protect it against her. It named him this substance by transference factor.

Shortly after the finds of Dr. Lawrence, the investigators understood that the animals were offering an effective and economic source of molecules of factors of transference. And although the transference factors were fulfilling a secondary roll as regards the "miracle" of the antibiotics, the investigators have carried out numerous studies to explore the safety and effectiveness of the factors of transference, and hundreds of scientific articles have been published, that document the benefits of the factors of transference for the global immune health as well as also for specific illnesses.

Information of the Factors of Transference

The transference factors are obtained breaking white globules, themselves that they get in a dialysis bag with a very thin mesh that only allows the step of very small particles of 10 kilodaltones or minors therefore they cannot contain virus, bacteria or fungi, chemically there are chains péptidas hidrofílicas highly polar, with acidic parts, and that have two regions: a variable and a constant. The partial sequence of the constant regions of some of them is already known. In addition to transferring the cellular immune answer in specific form, the FT have effects Además de transferir la respuesta inmune celular en forma específica, los FT tienen efectos
on the calcium channels, stimulating the transport of this ión in the cells, probably activating the answer in cells of the immune system.

The transference factors are therefore natural and microscopic molecules that reside in the bodies of all the animals. They are messengers who transmit the immune information about the presence of a threat to the immune system, be already external or internal, and on how answering appropriately, from immune cell to immune cell.

The transference factors transmit the immune information (recognition of the pathogenic agents and suitable immune answer) across the specific instigating, suppressive factors and antigen.

The instigating factor allows the transference factors to endorse the immune answer of adaptation to the viral infections, parasites, malices, bacterial illnesses and micobacterianas, infections for fungi, autoimmune disorders and neurological illnesses. This factor can transfer an immune answer in less than 24 hours and reduce significantly or eliminate the symptoms of the illness.

The suppressive factor prevents the immune system from reacting in excessive form, for example to the pollen and to other strange bodies, as well as also with itself as it is the case of the autoimmune disorder. The factor specific antigen transports tags that are vital so that the immune system identifies the microbes and the strange cells.

The transference factors are enclosed in the most primitive immune systems. Of for himself, the instigating and suppressive factors of the factors of transference are universal and they can transfer the immunity, crossing the barrier of the species. Consequently, the factors of transference of a cow can provide with immunity a person and visceversa.

An important fact is that the fact that they are so small, that is to say, of a less molecular weight to 10.000 kilodaltones, it does that they do not cause allergies and allows to preserve its maximum efficacy when they are consumed in oral form. In fact, the colostrum of all the mammals is rich in transference factors and it is vital for the newborn babies those who are provided with passive form of immunity on having consumed the same one during the breast-feeding or breast feeding.

The Factor of Transference in Mexico

The doctor Sergio Estrada Parra, Emeritus Teacher, Chief of the Department of Immunology of the National School of Biological Sciences of the National Polytechnic school of Mexico is the pioneer in Mexico in the development of the Factors of transference and ride working 30 years. Close to the seventies it had the support of Dr. González Ochoa, an eminent micólogo, that was employed at the missing Institute of Healthiness and Tropical diseases in Mexico to treat a patient with coccidioidomicosis, illness micótica that in a point becomes incurable, the patient is deteriorating and dies. Therefore there initiated looking donors who had positive immunity against this illness, initiating this way the making of the first factor of transference in Mexico. The patient treated with this factor of transference had spectacular results and the development of this technology caused a big interest. Por lo que iniciaron buscando donadores que tuvieran inmunidad positiva contra esta enfermedad, iniciando así la elaboración del primer factor de transferencia en México. El paciente tratado con este factor de transferencia tuvo resultados espectaculares y causó un gran interés el desarrollo de esta tecnología.

At present there have very good experiences in the Human Medicine already in the treatment of illnesses produced by bacteria, virus, yeasts and fungi and in illnesses as different as the tuberculosis, (meníngeal, renal and cutaneous) the leprosy, the coccidioidomicosis, the diabetes type not insulin-dependent II, the earache, the herpes Zoster and simply, the hepatitis B and C, the toxoplasmosis, the leishmahiasis, the asthma, allergies, acne, bronchitis, eczema, the atypical dermatitis, the rinitis, the artrosis reumatoide, the psoriasis, the multiple sclerosis or the sjogren, the illness of Crohn, chronic fatigue, fibromialgia, lupus, cold and flu, mouth ulcers, poisonings caused by the feeding and cancers like that of kidney, prostate, melanomas, linfomas, etc. and in general in any illness of infectious or auto-immune type.

Factor of Transference in Veterinarian

It has been successful in the treatment of illnesses of favourite animals like the distemper odistemper canine, mange demodésica. At present, diverse manufacturers offer transference factors in complements that change from finished colostrum dissected up to concentrated extracts of factors of transference. The factors of transference that have been extracted and concentrated offer a more powerful complement. Some manufacturers also combine the transference factors with additional ingredients that are considered to be beneficial for the immune answer. Los factores de transferencia que han sido extraídos y concentrados brindan un complemento más potente. Algunos fabricantes además combinan los factores de transferencia con ingredientes adicionales que son considerados beneficiosos para la respuesta inmunitaria.

In case of the exotic animals, there are small the reports of the use of this immunotherapy. In the particular case of the use of the factor of transference in the dolphins in security of Group Via Delphi it has given big results, has been used successfully in babies who for any circumstance have not sucked colostrum therefore they have been suplementadas in an artificial way with this product, with turned out that they indicate that an increase of the IgG exists in specific that are the first defense line in neonatos. Also it has been used in patients who study with weakening chronic illnesses, as the case of respiratory illnesses is chronicles caused by fungi, like the case of respiratory aspergilosis, where we have thought that it has the aptitude to modulate the inflammatory answer, this means that in the cases where a deficient answer of white cells exists, he promotes the formation of them in blood stream and in case of an irritated inflammatory reaction it tends to return the count leucocitario inside the normal status for the species. También ha sido usado en pacientes que cursan con enfermedades crónicas debilitantes, como es el caso de enfermedades respiratorias crónicas causadas por hongos, como el caso de aspergilosis respiratoria, donde hemos encontrado que tiene la capacidad de modular la respuesta inflamatoria, esto significa que en los casos donde existe una deficiente respuesta de células blancas, promueve la formación de ellas en torrente sanguíneo y en el caso de una reacción inflamatoria exacerbada tiende a regresar el conteo leucocitario dentro de los rangos normales para la especie.

Source: Magazine to Sound (Institute Route Delphi)

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